Adults who survived HPV-associated cancers appeared at a significant risk for HPV-associated second primary cancers, according a retrospective cohort study.
Additionally, the risk for developing most types of HPV-associated second primary cancers has increased over the last 4 decades.
“In our previously published manuscript, we found that there was a strong association between HPV infections occurring at different anatomic sites,” Ashish A. Deshmukh, PhD, MPH, assistant professor of management, policy and community health at The University of Texas Health School of Public Health, told HemOnc Today. “The findings in that study led to our curiosity to understand if there is an association between six HPV-related cancers.
“Our hypothesis was that survivors of index HPV-related cancers are at increased risk for developing second HPV-related cancers.”“We, therefore, were interested in studying the risk for developing second HPV-related cancers — occurring at same or different anatomic sites — among survivors of index HPV-related cancer,” he added. “Our hypothesis was that survivors of index HPV-related cancers are at increased risk for developing second HPV-related cancers.”
Deshmukh and colleagues used the SEER database to identify 113,272 survivors of HPV-associated cancers — including cervical, vaginal, vulvar, oropharyngeal, anal and penile cancers — diagnosed from 1973 to 2014.
Investigators lost 4.8% of survivors to follow-up.
Of the 73,085 women survivors of HPV-associated cancers, 1,397 developed HPV-associated second primary cancers. Of the 40,187 men survivors, 1,098 developed second cancers.
Researchers observed standard incidence ratios (SIRs) for HPV-associated second cancers of 6.2 (95% CI, 5.9-6.6) among women and 15.8 (95% CI, 14.9-16.8) among men.
The excess absolute risk per 10,000 person-years at risk was 18.2 among women compared with 53.5 among men.
Both men and women who had initial oropharyngeal cancers appeared to be at the highest risk for secondary primary cancers when assessing SIRs (men, 18; 95% CI, 16.9-19.1; women, 19.8; 95% CI, 18.4-21.4) and excess absolute risk per 10,000 person-years at risk (men, 61.5; women, 80.6).
Researchers observed the lowest risk for HPV-associated second primary cancers among…