Pap Tests May Help Diagnose Endometrial, Ovarian Cancers
PapSEEK, which incorporates assays for mutations in 18 genes and for aneuploidy in DNA recovered from fluids obtained during a routine Pap test, may aid in detection of endometrial and ovarian cancers, according to a study published online in Science Translational Medicine.
Yuxuan Wang, from the Johns Hopkins University School of Medicine in Baltimore, and colleagues reported the detection of endometrial and ovarian cancer with PapSEEK.
“These results demonstrate the potential of mutation-based diagnostics to detect gynecologic cancers at a stage when they are more likely to be curable,” the authors write.
The researchers found that 81% of Pap brush samples from 382 endometrial cancer patients were positive, including 78% with early-stage disease. Among 245 ovarian cancer patients…
Key Statistics for Endometrial Cancer
How common is endometrial cancer?
In the United States, cancer of the endometrium is the most common cancer of the female reproductive organs. The American Cancer Society estimates for cancer of the uterus in the United States for 2018 are:
- About 63,230 new cases of cancer of the body of the uterus (uterine body or corpus) will be diagnosed.
- About 11,350 women will die from cancers of the uterine body.
These estimates include both endometrial cancers and uterine sarcomas. Up to 8% of uterine body cancers are sarcomas, so the actual numbers for endometrial cancer cases and deaths are slightly lower than these estimates.
Lifetime chance of getting endometrial cancer
Endometrial cancer affects mainly postmenopausal women. The average age of women diagnosed with endometrial cancer is 60. It is uncommon in women under the age of 45.
This cancer is slightly more common in white women, but black women are more likely to die from it. There are more than 600,000 survivors of endometrial cancer.
Visit the American Cancer Society’s Cancer Statistics Center for more key statistics.